CXCR Gene and its Association with Mastitis Resistance in Cattle- a Review

Authors

  • Mahesh. S. Dige Division of Animal Genetics and Breeding, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP (243 122), India
  • G. R. Gowane Division of Animal Genetics and Breeding, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP (243 122), India
  • L. S. Kokate Division of Animal Genetics and Breeding, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP (243 122), India
  • Sunil Kumar B. V. Division of Biochemistry, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP (243 122), India
  • Bharat Bhushan Division of Animal Genetics and Breeding, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP (243 122), India

Keywords:

Chemokines, CXCR gene, Mastitis, Molecu­lar Markers, Resistance

Abstract

Genes associated with immune responses of mammary gland are potential genetic markers because of their importance in mastitis. Neutrophil functions are potential genetic markers for mastitis, as neutrophil migration from blood to the sites of infection is essential for resolution of most mastitis pathogens. The ability of neutrophils to migrate into infected tissues is dependent upon recognition of inflammatory mediators by neutrophil cytokines, chemokines, and complementary receptor. Among various chemokines, one of the important chemokine associated with leukocyte migration is interleukin-8 (IL-8). Being receiver and transmitter of the signal from IL-8 to down­stream, the receptors of IL-8 (CXCR) are the important candidate genes for mastitis tolerance/ susceptibility study in the cattle herd.

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Published

2023-04-27

How to Cite

1.
Dige MS, Gowane GR, Kokate LS, Kumar B. V. S, Bhushan B. CXCR Gene and its Association with Mastitis Resistance in Cattle- a Review. IJBSM [Internet]. 2023 Apr. 27 [cited 2025 Sep. 21];2(Dec, 4):444-7. Available from: https://ojs.pphouse.org/index.php/IJBSM/article/view/193

Issue

Vol. 2 No. Dec, 4 (2011)

Section

Articles

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